Travel by car from Palermo to Rome (5)
I believe the answer is:
motor
'travel by car' is the definition.
(I've seen this before)
'from palermo to rome' is the wordplay.
'from' says the answer is hidden in the clue.
'MOTOR' can be found hidden inside 'palermo to rome'.
(Other definitions for motor that I've seen before include "Move fast" , "Machine that converts energy into motion" , "Driver" , "Engine - relating to movement" , "Engine of vehicle" .)