Trendy food lacking the first hint of anything natural (6)
I believe the answer is:
inbred
'hint of anything natural' is the definition.
'inbred' can be an answer for 'natural' (I've seen this before). I'm not certain of the 'hint of anything' bit.
'trendy food lacking the first' is the wordplay.
'trendy' becomes 'in' ('in' can mean fashionable).
'food' becomes 'B' (B is an example).
'lacking the first' becomes 'red' (I can't explain this - if you can you should give a lot more credence to this answer).
'in'+'b'+'red'='INBRED'
Can you help me to learn more?
(Other definitions for inbred that I've seen before include "Inherent" , "Binder (anag)" , "4 across" , "Born of closely related people" , "Present by nature" .)