Trouble is to do with anagram helper (4,9)
I believe the answer is:
good samaritan
'helper' is the definition.
(good Samaritan is a kind of helper)
'trouble is to do with anagram' is the wordplay.
'trouble' is an anagram indicator.
'with' is a charade indicator (letters next to each other).
'is'+'to'+'do'='istodo'
'istodo' after 'anagram' is 'anagramistodo'.
'anagramistodo' with letters rearranged gives 'GOOD SAMARITAN'.
(Other definitions for good samaritan that I've seen before include "Compassionate person in Bible" , "Neighbourly type" , "One giving disinterested help, maybe to a stranger" , "One helping the needy" , "I'm a kind person" .)