Trouble when international organisation takes break (6)
I believe the answer is:
unrest
'trouble' is the definition.
(I've seen this before)
'international organisation takes break' is the wordplay.
'international organisation' becomes 'UN' (United Nations).
'takes' is a charade indicator (letters next to each other).
'break' becomes 'rest' (a rest is taking a break).
'un'+'rest'='UNREST'
'when' acts as a link.
(Other definitions for unrest that I've seen before include "Uneasiness; turmoil" , "Feeling of anxiety or turmoil" , "'Disturbance, agitation (6)'" , "Rebellious state" , "Discontent verging on insurrection" .)