Trouble with flies? A&E fixed up nether region (4,6)
I believe the answer is:
east anglia
'nether region' is the definition.
'east anglia' can be an answer for 'region' (region of England). I'm not certain of the 'nether' bit.
'trouble with flies? ae fixed up' is the wordplay.
'trouble' becomes 'ail' (synonyms).
'with' means one lot of letters go next to another.
'flies?' becomes 'gnats' ().
'fixed up' says the letters should be written in reverse (in a down clue, letters go up).
'ail'+'gnats'+'ae'='ailgnatsae'
'ailgnatsae' backwards is 'EAST ANGLIA'.
Can you help me to learn more?
(Other definitions for east anglia that I've seen before include "Region of England" , "Norfolk, Suffolk, part of Essex and Cambridgeshire" , "Steal again (anag.)" , "somewhere south of the Wash" , "Part of UK" .)