Trouble with rent may come as a big blow (7)
I believe the answer is:
tornado
'a big blow' is the definition.
(I've seen this in another clue)
'trouble with rent' is the wordplay.
'trouble' becomes 'ado' (both can mean bother or commotion).
'with' says to put letters next to each other.
'rent' becomes 'torn' (synonyms).
'ado' after 'torn' is 'TORNADO'.
'may come as' is the link.
I am not very happy about this link. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for tornado that I've seen before include "Destructive windstorm" , "Strong wind" , "Severe wind" , "Major storm" , "This is quite a blow" .)