Try me, running around large shrub (6)
I believe the answer is:
myrtle
'shrub' is the definition.
(myrtle is a kind of shrub)
'try me running around large' is the wordplay.
'running' is an anagram indicator (the letters run around to different places).
'around' is an insertion indicator.
'large' becomes 'L' (eg in clothes sizes).
'try'+'me'='tryme'
'tryme' with letters rearranged gives 'myrte'.
'myrte' enclosing 'l' is 'MYRTLE'.
(Other definitions for myrtle that I've seen before include "Evergreen shrub - try elm (anag)" , "Eugenia perhaps" , "Bush" , "Plant with aromatic blue-black berries" , "Evergreen shrub with blue-black berries" .)