Try to get a lift in east Humberside (5)
I believe the answer is:
thumb
'try to get a lift' is the definition.
(reference to hitch-hiking)
'in east humberside' is the wordplay.
'in' indicates the answer is hidden within the clue.
'THUMB' can be found hidden inside 'east humberside'.
(Other definitions for thumb that I've seen before include "''Tom ..., the piper's son'' (nursery rhyme)" , "Stubby digit?" , "Tom ___ , traditional hero of English folklore" , "Hitch (a lift)" , "Travel by . . . . . - hitchhike" .)