Try to make money having lost your shirt? (6)
I believe the answer is:
invest
'try to make money' is the definition.
(people make investments in order to make money)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for invest that I've seen before include "Eg, buy stocks and shares" , "Buy shares; besiege" , "Contribute money in hope of a return" , "sink" , "Lay siege" .)