Turn up with lb50 too much for a garment (8)
I believe the answer is:
pullover
'for a garment' is the definition.
(pullover is a kind of garment)
'turn up' is the wordplay.
'turn' becomes 'pull' (I can't explain this - if you can you should give a lot more credence to this answer).
'up' becomes 'over'.
'pull'+'over'='PULLOVER'
'with lb50 too much' acts as a link.
This may not be correct. Some or all of it may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for pullover that I've seen before include "Knitted garment" , "Jersey" , "Sweater or jumper" , "top gear?" , "Woolly" .)