Twelve back-to-back refusals (4)
I believe the answer is:
noon
'twelve' is the definition.
(twelve noon)
I cannot understand how the remainder of the clue works.
(Other definitions for noon that I've seen before include "when only mad dogs go out?" , "when PM starts" , "Twelve o'clock, midday" , "The middle of the day" , "12 o'clock" .)