Twente Enschede's youngsters (5)
I believe the answer is:
'youngsters' is the definition.
(I've seen this in another clue)
'twente enschede's' is the wordplay.
'TEENS' is hidden in amongst the letters.
But, I am uncertain how this is indicated.
(Other definitions for teens that I've seen before include "Between 12 and 20" , "Years 13-19" , "children" , "Adolescent years" , "Adolescence" .)