Twice it returns with an artist of fame (6)
I believe the answer is:
titian
'artist of fame' is the definition.
'Titian' can be an answer for 'artist' (Titian is an example). I'm not sure about the 'of fame' bit.
'twice it returns with an' is the wordplay.
'twice' indicates the doubling of some letters.
'returns' says the letters should be written in reverse.
'with' is a charade indicator (letters next to each other).
'it' backwards is 'ti'.
'ti' doubled is 'titi'.
'titi'+'an'='TITIAN'
Can you help me to learn more?
(Other definitions for titian that I've seen before include "The painter Tiziano Vecellio" , "Italian painter, d. 1576" , "Painter, noted for works with bright auburn hair" , "Venetian artist" , "Reddish-gold; painter" .)