Crossword Genius

Twice self-employed in cultural unit (4)

Ross

I believe the answer is:

meme

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'twice self-employed in cultural unit' is the definition.
The definition suggests a singular noun which matches the answer.

'in cultural unit' is the wordplay.
'in' is an insertion indicator.
'cultural' becomes 'me' (I can't justify this - if you can you should believe this answer much more).
'unit' becomes 'em' (em is a kind of unit).
'me' enclosing 'em' is 'MEME'.

Can you help me to learn more?

(Other definitions for meme that I've seen before include "Often trite image" , "Concept that spreads rapidly on the Internet" , "Cultural belief that assumes a life of its own" , "Behavioural trait" , "Question that spreads on the internet" .)

I've seen this clue in The Telegraph.
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