Twice set out to find fly (6)
I believe the answer is:
tsetse
'fly' is the definition.
(biting fly found in tropical Africa)
'twice set out to' is the wordplay.
'twice' says to double the letters.
'set' becomes 'tv' (TV set).
'out' means to remove the last letter.
'to' becomes 'se' (I can't explain this - if you can you should believe this answer much more).
'tv' with its final letter removed is 't'.
't'+'se'='tse'
'tse' doubled is 'TSETSE'.
'find' is the link.
Can you help me to learn more?
(Other definitions for tsetse that I've seen before include "fly across Africa" , "Disease-carrying fly" , "carrier of disease" , "cause of sleepiness?" , "African transmitter" .)