Twice set out to fly (6)
I believe the answer is:
tsetse
'fly' is the definition.
(biting fly found in tropical Africa)
'twice set out to' is the wordplay.
'twice' shows that letters should be duplicated.
'set' becomes 'TV' (TV set).
'out' means to remove the last letter.
'to' becomes 'se' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'tv' with its final letter taken off is 't'.
't'+'se'='tse'
'tse' duplicated is 'TSETSE'.
Can you help me to learn more?
(Other definitions for tsetse that I've seen before include "fly across Africa" , "Disease-carrying fly" , "source of sleeping sickness" , "flies" , "African transmitter" .)