Twist and odds come down (6)
I believe the answer is:
sprain
'twist' is the definition.
(sprain is a kind of twist)
'odds come down' is the wordplay.
'odds' becomes 'sp' (betting abbreviation for starting price).
'come down' becomes 'rain' (raining is a kind of coming down).
'sp'+'rain'='SPRAIN'
'and' is the link.
(Other definitions for sprain that I've seen before include "Wrench (an ankle) 6)" , "Wrench or twist" , "Wrench (a ligament) (P, not T)" , "Muscle injury caused by wrench." , "Injure a joint by twisting its ligaments" .)