Twist betting on bad conditions (6)
I believe the answer is:
sprain
'twist' is the definition.
(sprain is a kind of twist)
'betting on bad conditions' is the wordplay.
'betting' becomes 'sp'.
'on bad conditions' becomes 'rain' (I can't justify this - if you can you should believe this answer much more).
'sp'+'rain'='SPRAIN'
Can you help me to learn more?
(Other definitions for sprain that I've seen before include "Wrench a joint" , "Twist ligament(s)" , "Strain (eg, ankle)" , "Injury to the ankle, say" , "Muscle injury caused by wrench." .)