Twist smart speaker's lead around (4)
I believe the answer is:
spin
'twist' is the definition.
(I know that twist can be written as spin)
'smart speaker's lead around' is the wordplay.
'smart' becomes 'nip' (both can mean a pain).
'lead' suggests taking the first letters.
'around' says the letters should be written in reverse.
The first letter of 'speakers' is 's'.
'nip'+'s'='nips'
'nips' back-to-front is 'SPIN'.
(Other definitions for spin that I've seen before include "Make thread; go round" , "Gyrate, reel" , "Rapidly rotate" , "what some bowlers hope for" , "Political interpretation; rotate" .)