Twisted point to a witticism (4)
I believe the answer is:
spun
'twisted' is the definition.
(spinning is a kind of twisting)
'point to a witticism' is the wordplay.
'point' becomes 's' (South).
'to a witticism' becomes 'pun' (pun is a kind of witticism).
's'+'pun'='SPUN'
(Other definitions for spun that I've seen before include "(Of cotton/wool) twisted into threads" , "Drawn out and twisted (like yarn)" , "Made up (a yarn)" , "Rapidly rotated" , "treated by doctors?" .)