Twisted spine is odd being laid up (10)
I believe the answer is:
indisposed
'laid up' is the definition.
(thesaurus)
'twisted spine is odd' is the wordplay.
'twisted' indicates an anagram.
'spine'+'is'+'odd'='spineisodd'
'spineisodd' with letters rearranged gives 'INDISPOSED'.
'being' acts as a link.
(Other definitions for indisposed that I've seen before include "Slightly unwell" , "Out of sorts" , "Poorly" .)