Twisted young woman beginning to harass a writer (9)
I believe the answer is:
misshapen
'twisted' is the definition.
(thesaurus)
'young woman beginning to harass a writer' is the wordplay.
'young woman' becomes 'miss' (synonyms).
'beginning to' says to take the initial letters.
'writer' becomes 'pen' (I've seen this before).
The first letter of 'harass' is 'h'.
'miss'+'h'+'a'+'pen'='MISSHAPEN'
(Other definitions for misshapen that I've seen before include "Badly formed" , "Ugly in form" , "showing bad form" , "Badly designed" , "Not looking round" .)