Typical guest unable to be regularly ignored (5)
I believe the answer is:
usual
'typical' is the definition.
(I've seen this in another clue)
'guest unable to be regularly ignored' is the wordplay.
'to be regularly ignored' means one should take alternating letters (letters removed at regular intervals).
'guest'+'unable'='guestunable'
The alternating letters of 'guestunable' are 'USUAL'.
(Other definitions for usual that I've seen before include "Normal, habitual" , "Expected" , "Normally done" , "familiar" , "In accordance with regular practice" .)