Ultimately appreciate Banksy the street artist's fashionable - an issue for some readers (9)
I believe the answer is:
eyestrain
'an issue for some readers' is the definition.
I can't tell whether this defines the answer.
'ultimately appreciate banksy the street artist's fashionable' is the wordplay.
'ultimately' says to take the final letters.
'street' becomes 'st' (abbreviation).
'artist' becomes 'RA' (Royal Academician, member of Royal Academy of Arts).
'fashionable' becomes 'in' (in can mean fashionable or trendy).
The final letters of 'appreciate banksy the' are 'eye'.
'eye'+'st'+'ra'+'in'='EYESTRAIN'
Can you help me to learn more?
(Other definitions for eyestrain that I've seen before include "pupils are involved in such trouble" , "tiredness of pupils" , "Vision problem" , "Tiredness when reading" , "Difficulty for reader" .)