Ultimately blunted instrument: Prince Andrew, say (4)
I believe the answer is:
duke
'prince andrew say' is the definition.
I can't tell whether this definition defines the answer.
'ultimately blunted instrument' is the wordplay.
'ultimately' suggests the final letters.
'instrument' becomes 'uke' (short for ukulele).
The final letter of 'blunted' is 'd'.
'd'+'uke'='DUKE'
Can you help me to learn more?
(Other definitions for duke that I've seen before include "Nobleman - fist" , "Highest hereditary title in Britain" , "Nickname of John Wayne" , "High hereditary title in Britain" , "Fist (sl.)" .)