Uncomfortable in someone else's house? (3,2,4)
I believe the answer is:
not at home
'someone else's house?' is the definition.
I don't know anything about this answer so I can't judge whether this works.
'uncomfortable in' is the wordplay.
'uncomfortable' becomes 'not' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'in' becomes 'at home' (someone at home is 'in').
'not'+'athome'='NOT AT HOME'
Can you help me to learn more?
(Other definitions for not at home that I've seen before include "barking at the moon" , "Ignoring visitors" .)