Unfavourable, contrary (7)
I believe the answer is:
adverse
This clue is a double definition.
'unfavourable' is the first definition.
(similar in meaning)
'contrary' is the second definition.
(synonyms)
(Other definitions for adverse that I've seen before include "Unfavourable - red vase (anag)" , "Unfavourable or harmful, perhaps criticism" , "Inopportune" , "Opposed - inauspicious - opposite" , "In an opposing direction" .)