Unfortunately the lady's been upset (5)
I believe the answer is:
sadly
'unfortunately' is the definition.
(synonyms)
'lady's been upset' is the wordplay.
'been upset' indicates an anagram (I've seen 'are upset' mean this).
'ladys' with letters rearranged gives 'SADLY'.
'the' acts as a link.
(Other definitions for sadly that I've seen before include "I regret to say" , "Alas" , "Regrettably" , "Mournfully" , "Unhappily" .)