Unfriendly, shifty clod (4)
I believe the answer is:
cold
'unfriendly' is the definition.
(similar in meaning)
'shifty clod' is the wordplay.
'shifty' indicates anagramming the letters.
'clod' anagrammed gives 'COLD'.
(Other definitions for cold that I've seen before include "See 12" , "Unfriendly" , "Chilly; unemotional" , "Frigid" , "Lacking warmth" .)