Unhappy at university clique (5)
I believe the answer is:
upset
'unhappy' is the definition.
(I've seen this before)
'at university clique' is the wordplay.
'at university' becomes 'up'.
'clique' becomes 'set' (I've seen this before).
'up'+'set'='UPSET'
(Other definitions for upset that I've seen before include "Surprising result" , "Disturb, physically or emotionally" , "Discomfit" , "Disrupted; knock over" , "bug" .)