Uninterested, world-weary (5)
I believe the answer is:
bored
I believe this is a double definition.
'uninterested' is the first definition.
(similar in meaning)
'world-weary' is the second definition.
(I know that world-weary can be written as bored)
(Other definitions for bored that I've seen before include "Fed up, afflicted with ennui" , "Brassed off" , "Used drill on" , "Weary and impatient" , "Fed up - tired of the world" .)