Unique flatfish (4)
I believe the answer is:
sole
This clue is a double definition.
'unique' is the first definition.
(synonyms)
'flatfish' is the second definition.
(sole is a kind of flatfish)
(Other definitions for sole that I've seen before include "Kind of fish - lose it" , "O __ Mio (Neapolitan song)" , "European flatfish" , "One and only; part of foot" , "piece of leather" .)