University starts to require registration in crucial changes relating to course (10)

'relating to course' is the definition.
(I know this)

'university starts to require registration in crucial changes' is the wordplay.
'university' becomes 'U' (abbreviation for university).
'starts to' suggests taking the first letters.
'in' indicates putting letters inside.
'changes' is an anagram indicator.
The initial letters of 'require registration' is 'rr'.
'u'+'rr'='urr'
'crucial' anagrammed gives 'cicular'.
'urr' put inside 'cicular' is 'CURRICULAR'.