Unpleasant noise from snake trailing Queen (4)
I believe the answer is:
rasp
'unpleasant noise' is the definition.
(I've seen this before)
'snake trailing queen' is the wordplay.
'snake' becomes 'asp' (asp is a kind of snake).
'trailing' says to put letters next to each other.
'queen' becomes 'r' (abbreviation for regina, e.g. in ER ).
'asp' after 'r' is 'RASP'.
'from' acts as a link.
(Other definitions for rasp that I've seen before include "Smoother" , "It is used to grate" , "File - berry" , "Grating noise; file" , "Harsh noise - file" .)