Unsympathetic company over pounds and pence (4)
I believe the answer is:
cold
'unsympathetic' is the definition.
(I've seen this before)
'company over pounds and pence' is the wordplay.
'company' becomes 'co' (abbreviation).
'over' means one lot of letters go next to another (in a down clue, some letters go over others).
'pounds' becomes 'l' (abbreviation e.g. Lsd - pounds, shillings, pence).
'and' is a charade indicator (letters next to each other).
'pence' becomes 'd' (abbreviation e.g. Lsd - pounds, shillings, pence).
'co'+'l'+'d'='COLD'
(Other definitions for cold that I've seen before include "Mild viral infection, very common" , "Chill" , "Chilly; minor ailment" , "Frigid" , "Unemotional; infection" .)