Unusual, as a vacation (6)
I believe the answer is:
exotic
'unusual as a vacation' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for exotic that I've seen before include "Bizarre" , "Strikingly different/colourful" , "Strange, rare or foreign" , "Romantically strange" , "Foreign-looking" .)