Up and running with tons of rubbish and a lot of paper (2-6)

'up and running' is the definition.
(I've seen this in another clue)

'tons of rubbish and a lot of paper' is the wordplay.
'of rubbish' is an anagram indicator (I've seen 'rubbish' mean this (a poor quality or rubbish spelling of the letters)).
'and' is a charade indicator (letters next to each other).
'a lot of paper' becomes 'ream' (I've seen this in another clue).
'tons' is an anagram of 'onst'.
'onst'+'ream'='ON-STREAM'

'with' acts as a link.