Uplifting story about one port (5)
I believe the answer is:
eilat
'port' is the definition.
(Israeli port)
'uplifting story about one' is the wordplay.
'uplifting' shows that the letters should be reversed in order.
'story' becomes 'tale' (synonyms).
'about' means one lot of letters goes inside another.
'one' becomes 'I' (Roman numeral).
'tale' placed around 'i' is 'talie'.
'talie' reversed gives 'EILAT'.
(Other definitions for eilat that I've seen before include "Gulf of Aqaba port" , "Red Sea resort" , "Israeli resort" , "Israel's Red Sea port" , "city" .)