Upset, agitate (7)
I believe the answer is:
disturb
I believe this is a double definition.
'upset' is the first definition.
(synonyms)
'agitate' is the second definition.
(I know that agitate is a more specific form of disturb)
(Other definitions for disturb that I've seen before include "Intrude on" , "Unsettle, discomfit" , "Interrupt; upset" , "Agitate - ruffle - trouble" , "Discompose" .)