Upset with doctor injecting drug, amateur, no good with efficiency primarily (7)
I believe the answer is:
derange
'amateur no good with efficiency primarily' is the definition.
I can't judge whether this defines the answer.
'upset with doctor injecting drug' is the wordplay.
'upset' becomes 'ange' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'with' says to put letters next to each other.
'doctor' becomes 'Dr' (synonyms).
'injecting' is an insertion indicator.
'drug' becomes 'e' (E is another name for ecstasy).
'dr' placed around 'e' is 'der'.
'ange' put after 'der' is 'DERANGE'.
Can you help me to learn more?
(Other definitions for derange that I've seen before include "Upset" , "Craze" , "Madden" , "Make insane" , "Remove from order" .)