Uptight doctor cried at last (6-5)
I believe the answer is:
strait-laced
'uptight' is the definition.
(strait-laced means uptight or prudish)
'doctor cried at last' is the wordplay.
'doctor' is an anagram indicator.
'cried'+'at'+'last'='criedatlast'
'criedatlast' anagrammed gives 'STRAIT-LACED'.
(Other definitions for strait-laced that I've seen before include "Narrow-minded" , "Prudish" , "Strictly moral" , "Having strict morals" .)