US city enveloped in love for Little Italy in the future (3,4)
I believe the answer is:
any more
'in the future' is the definition.
(eg 'not any more' means 'not in the future')
'us city enveloped in love for little italy' is the wordplay.
'us city' becomes 'NY' (short for New York).
'enveloped in' is an insertion indicator.
'love for little italy' becomes 'amore' ('love' in Italian).
'ny' placed within 'amore' is 'ANY MORE'.
(Other definitions for any more that I've seen before include "'Annie doesn't live here - - '" , "Still further" .)