U.S. novel in translation defeats one (4,2,4)

I believe the answer is:

east of eden

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'u s novel' is the definition.
'east of eden' can be an answer for 'novel' (I've seen this before). I'm unsure of the 'u s' bit.

'translation defeats one' is the wordplay.
'translation' indicates an anagram.
'defeats'+'one'='defeatsone'
'defeatsone' with letters rearranged gives 'EAST OF EDEN'.

'in' is the link.

Can you help me to learn more?

(Other definitions for east of eden that I've seen before include "Book and film" , "Steinbeck novel" , "Book by Steinbeck" , "one by Steinbeck" .)

I've seen this clue in The Everyman puzzle in The Observer.

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