US river and state (8)
I believe the answer is:
missouri
'us river and state' is the definition.
(I've seen this before)
This is the entire clue.
(Other definitions for missouri that I've seen before include "Biggest tributary of the Mississippi" , "Midwestern US state" , "So is rum I alter to the state" , "US river - state" , "US state, capital Jefferson City" .)