Use a different biblical character (4)
I believe the answer is:
esau
'biblical character' is the definition.
(I've seen this before)
'use a different' is the wordplay.
'different' is an anagram indicator.
'use'+'a'='usea'
'usea' with letters rearranged gives 'ESAU'.
(Other definitions for esau that I've seen before include "Jacob's twin (Bible)" , "Big Brother" , "Hairy biblical man" , "Son of Isaac, brother to Jacob (Bible)" , "One of Isaac's sons" .)