Use aged sire and take issue (8)
I believe the answer is:
disagree
'take issue' is the definition.
(synonyms)
'use aged sire' is the wordplay.
'use' is an anagram indicator.
'aged'+'sire'='agedsire'
'agedsire' with letters rearranged gives 'DISAGREE'.
'and' acts as a link.
(Other definitions for disagree that I've seen before include "Be at odds" , "Take issue with, hold different opinion" , "Beg to differ" , "Quarrel" , "Differ in opinion" .)