Useless dope taking over — resentment generally high (7)
I believe the answer is:
dudgeon
'resentment generally high' is the definition.
(often worded as 'high dudgeon')
'useless dope taking' is the wordplay.
'useless' becomes 'dud' (I've seen this before).
'dope' becomes 'ge' (I can't explain this - if you can you should give a lot more credence to this answer).
'taking' becomes 'on' (eg one taking drugs is 'on' drugs).
'dud'+'ge'+'on'='DUDGEON'
'over' is the link.
I am not very happy about this link. It may belong to another bit of the clue.
(Other definitions for dudgeon that I've seen before include "Umbrage" , "Deep resentment" , "feeling of resentment" , "Offended indignation" , "Feeling of intense indignation" .)