Using odd bits of turkey, guys cook American -- awesome! (10)
I believe the answer is:
tremendous
'awesome' is the definition.
(I've seen this in another clue)
'using odd bits of turkey guys cook american' is the wordplay.
'using odd bits of' indicates alternate letters (letters in odd-numbered positions).
'guys' becomes 'men' (guy can mean a man).
'cook' becomes 'do' (do can mean to cook).
'american' becomes 'us' (abbreviation for United States).
The alternate letters of 'turkey' are 'tre'.
'tre'+'men'+'do'+'us'='TREMENDOUS'
(Other definitions for tremendous that I've seen before include "large" , "Terrific" , "Immense" , "Fantastic" , "Splendid!" .)