V-sign changes? (6)
I believe the answer is:
varies
'changes?' is the definition.
('vary' can be a synonym of 'change')
'v-sign' is the wordplay.
'sign' becomes 'Aries' (star sign).
'v'+'aries'='VARIES'
(Other definitions for varies that I've seen before include "'Alters, changes (6)'" , "Tends to change" , "Differs, changes" , "Makes or becomes different, changes" , "Changes, deviates" .)