Vacuous rubbish about twisted family comeback (7)
I believe the answer is:
rebirth
'comeback' is the definition.
(I've seen this in another clue)
'vacuous rubbish about twisted family' is the wordplay.
'vacuous' says to hollow out the word (remove centre letters).
'about' indicates putting letters inside.
'twisted' shows that the letters should be reversed in order.
'family' becomes 'tribe' (I've seen this in other clues).
'rubbish' with its middle taken out is 'rh'.
'tribe' back-to-front is 'ebirt'.
'rh' going around 'ebirt' is 'REBIRTH'.
(Other definitions for rebirth that I've seen before include "second coming" , "Renascence" , "Spiritual renewal" , "Renaissance" , "Start of a new life?" .)